AY Mail 2. Any Edition
If you have a "Do Not Send" list, you can configure AY Mail not
to send to addresses from this list under any circumstances.
The global blacklist will affect sending from every project.
In addition to the global blacklist, AY Mail 2 Professional or Corporate
Edition lets you select individual blacklists for projects.
Your blacklists can be almost anywhere
(Internet, File, Database, AY Mail 2 Project etc.)
Once you select the blacklists, it will affect all your subsequent
mailings. All the addresses on the lists will be automatically exluded.
AY Mail will load the blacklists from the specified sources
every time you do a mailing, so if you change the blacklists
at the source, it will automatically change in AY Mail.
See How to use blacklists